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Immune Response of the Human Respiratory Tract

I. Immunoglobulin Levels and Influenza Virus Vaccine Antibody Response¹

From the University of Florida College of Medicine, Gainesville, Florida 32601

Abstract

Immunoglobulin levels and antibody titers were determined in bronchoalveolar (BA) lavage fluids, nasal washings, and sera from volunteers immunized with a commercial inactivated influenza virus vaccine by aerosol or subcutaneously. The IgG:IgA ratio of BA secretions was 2.5:1, thus being intermediate between the ratio in sera and nasal washings. Little albumin was found in the BA fluids. BA antibody was best stimulated by local (aerosol) immunization, was found in the IgG, as well as IgA class of immunglobulins and was locally produced.

Footnotes

¹ This work was supported by National Institutes of Health Grants AI-0341-05 and AI-10295-02 and by The Irwin Strasburger Memorial Medical Foundation.

² Recipient of National Institutes of Health Research Career Development Award No. AI-36631-02.

³ Recipient of Florida Tuberculosis and Respiratory Disease Association Christmas Seal Fellow.

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