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The Role of C in Allergen-Reagin Mediated Histamine Release Reactions

Oregon Primate Center, Beaverton, Oregon

Abstract

Preliminary studies demonstrated that either a C3 inactivator isolated from human serum or a monospecific antihuman C3 serum gave a linear dose-dependent inhibition of allergenreagin-induced histamine release reactions from monkey lung tissue (MLT) passively sensitized with human reagin. These observations suggested that the role of C in allergic reactions should be re-examined with respect to the recently described alternate pathway of C action.

The results of these studies demonstrated that 1) C3, 5, 6, 8, 9, C3 proactivator (C3PA), and properdin are bound to MLT, and 2) monospecific antisera directed against the above components show a dose-dependent inhibition of allergen-reagin induced histamine release from MLT. Specificity of the above antisera to inhibit allergen-reagin induced histamine release was seen by the failure to demonstrate inhibition with the following reagents: 1) anti-C4, 2) anti-BSA, and 3) anti-rhesus lung tissue sera. The question of desensitization of MLT explaining the inhibition of the observed reactions was evaluated by three different approaches.