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Genetic Control of Immune Response toward the Loop Region of Lysozyme¹

From the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

Abstract

Analysis of the immune response toward the lysozyme "loop" region attached to multichain poly-dl-alanine (loop-A-L) in DBA/1 (high responder) and SJL (low responder) mouse strains, as well as in their F₁ hybrids and backcrosses, showed that the antibody production to loop is genetically controlled by a unigenic dominant trait, which is not linked to the major histocompatibility locus H-2.

The strain-dependent differences, in the response to the loop, observed previously upon immunization with loop-A—L, were now confirmed with the loop-Pro—L (loop attached to multichain polyproline) conjugate, with the exception of the SWR mice—high responders to loop-A-L and low responders to loop-Pro-L—which were also found incapable of responding to the Pro-L carrier.

Immunization of several inbred mouse strains with conjugates of a synthetic loop derivative yielded similar strain-dependent differences to those obtained with the conjugates of the natural lysozyme loop.

Footnotes

¹ This work was supported in part by agreements 06-035 and 06-010 with the National Institutes of Health, United States Public Health Service.

² Address correspondence to: Professor Ruth Arnon, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel.