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Immunochemical Study of Group a Streptococcus Peptidoglycan Solubilized by 8 M Urea¹

From the Laboratories de Recherches, Chateau de Longchamp, Bois de Boulogne, 75016 Paris, France

Abstract

Group A streptococcal cell walls, after extraction by formamide, may be partially solubilized in aqueous 8 M urea. This soluble peptidoglycan is not immunogenic, but contains material which precipitates strongly with group A streptococcus polysaccharide antisera as well as with antipeptidoglycan antisera. This immunologic reactivity is due to a free N-acetyl-glucosamine grouping. Coupling urea-soluble peptidoglycan with bovine serum albumin makes it immunogenic on the rabbit. Antibodies produced are directed to the peptidic moiety of peptidoglycan.

Footnotes

¹ This study was supported by the French Institute for Health and Medical Research (Institut National de la Santé et de la Recherche Médicale), Research Contract 7140193.