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Prevention of Mif Activity by Agents Known to Increase Cellular Cyclic Amp¹

From the Departments of Medicine, Harvard Medical School and Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

Agents known to increase intracellular levels of cyclic 3'5' adenosine monophosphate (cyclic AMP), in a variety of tissues were examined for their effect on migration inhibitory factor (MIF)-induced inhibition of macrophage migration. -Adrenergic agents (isoproterenol and epinephrine) and prostaglandins E₁ and E₂ consistently prevent MIF activity on macrophage migration. Aminophylline also prevents MIF activity. These observations suggest a possible role for cyclic AMP in modulating the biologic activity of MIF. The finding that dibutyryl cyclic AMP inhibits MIF activity supports this view.

Footnotes

¹ This work was supported in part by United States Public Health Service Grants Al-7685-07, AM-05577, Am-12051, RR-05669, and a grant from the John A. Hartford Foundation.