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Immunity to Chlamydial Infections of the Eye

I. The Role of Circulatory and Secretory Antibodies in Resistance to Reinfection with Guinea Pig Inclusion Conjunctivitis¹

From the Department of Microbiology, Harvard School of Public Health, Boston, Massachusetts 02115

Abstract

Different types of immunologic stimuli were given to two separate groups of guinea pigs. One group received active conjunctival infection with live guinea pig inclusion conjunctivitis (gp-ic) organisms, another, formalin-killed gp-ic organisms intraperitoneally. Neutralizing complement-dependent serum antibodies were produced by both stimuli. However, immunity to conjunctival infection rechallenge developed only in those guinea pigs originally infected conjunctivally with live organisms. The latter animals were also the only ones to develop specific gp-ic secretory IgA antibodies in eye secretions. These studies cast doubt on the importance of specific serum antibodies in resistance to gp-ic conjunctival infection. The role of specific gp-ic secretory IgA antibodies as well as of cellular immunity in resistance to gp-ic infection is discussed.

Footnotes

¹ This work was supported by the Arabian American Oil Co., Dhahran, Saudi Arabia, and by grants to the Harvard School of Public Health from the National Institutes of Health (General Research Support Grant RR05446 and Training Grant 5-T01-A100014) and the National Eye Institute (9R01-EY-00812).