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Retention of Lymphocyte Characteristics by Myelomas and ⁺-Lymphomas: Sensitivity to Cortisol and Phytohemagglutinin¹

From the Salk Institute for Biological Studies, P.O. Box 1809, San Diego, California 92112

Abstract

Seven ⁺murine lymphomas in culture are very sensitive to killing by phytohemagglutinin; myeloma cell lines and a myeloid leukemia in culture are resistant. Pokeweed mitogen exerts an inhibitory effect both on lymphomas and myelomas, but only at high concentrations. Most of the lymphomas are inhibited by 10^-6 M cortisol whereas myeloma cells are generally resistant to the steroid at 10^-4 M. However, some IgA myelomas are as sensitive as lymphomas.

Footnotes

¹ This work was supported by the Ford Foundation and National Institute of Allergy and Infectious Diseases Research Grant AI-05875 to Dr. Melvin Cohn.

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