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Site of Deposition of C3 in Arthus Reactions of C4 Deficient Guinea Pigs

From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

The site of C3 deposition in the direct Arthus reaction induced in a strain of guinea pigs with a nonoperative classical complement pathway but a functional alternate complement pathway (C4 deficient animals) was examined. The area of hemorrhage, induration, and erythema was identical in these animals and controls. The lesions in homozygous C4 deficient animals showed normal infiltration of neutrophils and normal deposition of C3 by immuno-fluorescent visualization; thus the alternate complement pathway could successfully mediate this inflammatory event.