HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Colley, D. G. Search for Related Content PubMed Articles by Colley, D. G.

Eosinophils and Immune Mechanisms

I. Eosinophil Stimulation Promoter (ESP): A Lymphokine Induced by Specific Antigen or Phytohemagglutinin¹

From the Department of Microbiology, Vanderbilt University and the Veterans' Administration Hospital, Nashville, Tennessee 37232

Abstract

Exposure of eosinophil-rich peritoneal cell populations obtained from Schistosoma mansoni-infected mice to a soluble schistosomal egg antigen stimulates eosinophil migration. Supernatant fluids from serum-free lymph node cell cultures stimulated with antigens to which the donor mice had been specifically sensitized, or stimulated with phytohemagglutinin, also stimulate eosinophil migration. The active principle in such culture supernatant fluids is soluble, nondialyzable and heat-stable (56°C/30 min). It is tentatively classed as a lymphokine and designated eosinophil stimulation promoter.

Footnotes

¹ This study was supported by the Veterans' Administration and by United States Public Health Service Grant AI-08399.

This article has been cited by other articles:

				A Capron, J. Dessaint, M Capron, J. Ouma, and A. Butterworth Immunity to schistosomes: progress toward vaccine Science, November 20, 1987; 238(4830): 1065 - 1072. [Abstract] [PDF]