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The Genetics of the Immune Response to a Synthetic Double-Stranded RNA in a Mutant CBA Mouse Strain¹

From the Rheumatology Branch, Medicine Service, Naval Hospital, National Naval Medical Center and the Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

A mutant strain of mice (CBA/HN) was found that did not form antibody to the synthetic double-stranded ribonucleic acid polyinosinic-polycytidylic acid when given with complete Freund's adjuvant. All other strains investigated responded to this antigen. Genetic studies revealed that the inability to respond to this antigen was secondary to a gene on the X chromosome of the CBA/HN strain. Antibody formation could be induced in this strain by giving the antigen with methylated bovine -globulin. Immune responsiveness was transferred to nonresponding animals via lymphoid cells. The possible mechanisms of this defect are discussed.

Footnotes

¹ The opinions and assertions contained herein do not necessarily reflect the views of the Bureau of Medicine and Surgery of the Navy Department, or of the naval service at large.

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