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Demonstration of Proliferation by Bone Marrow-Derived Lymphocytes of Guinea Pigs, Mice and Rabbits in Response to Mitogen Stimulation in Vitro

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

We have shown by simultaneous complement receptor lymphocyte rosette and radioautographic techniques that guinea pig, mouse, and rabbit bone marrow-derived (B) cells proliferate in vitro in response to phytohemagglutinin, concanavalin A, pokeweed mitogen, and S. typhosa endotoxin lipopolysaccharide. PHA, Con A, and PWM are predominantly thymus-derived (T) cell mitogens in the guinea pig, mouse and rabbit. LPS is predominantly a B cell stimulant in the guinea pig but predominantly a T cell stimulant in the mouse.

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				S. Sell and H. W. Sheppard Jr. Rabbit Blood Lymphocytes May Be T Cells with Surface Immunoglobulins Science, November 9, 1973; 182(4112): 586 - 587. [Abstract] [PDF]