HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hütteroth, T. H. Articles by Litwin, S. D. Search for Related Content PubMed Articles by Hütteroth, T. H. Articles by Litwin, S. D.

Modulation of Membrane Associated Immunoglobulins of Cultured Human Lymphoid Cells by Specific Antibody¹

From The Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York, New York 10021

Abstract

Modulation of membrane associated immunoglobulins by specific antibodies was studied on lymphoid cells of established suspension cultures derived from four normal individuals. Changes in and µ surface immunoglobulins were monitored by the mixed antiglobulin reaction. Exposure to anti- antiserum led to rapid disappearance of both and µ antigen; exposure to anti-µ antiserum resulted in complete loss of µ antigen, while antigens were unaffected or only partially affected. Restoration of and µ antigens occurred from 3 to 12 hr. Monovalent antibody was unable to modulate surface immunoglobulins. Modulation would not occur at low temperature or in the presence of sodium azide.

Footnotes

¹ This work was aided by Grants AI-09239 and AM-11796 from the United States Public Health Service.

² Recipient of a stipend from the Stiftung Volkswagenwerk.

³ Recipient of United States Public Health Service Career Development Award AM-20122.