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Physical Association of Two Nuclear Antigens and Mutual Occurrence of Their Antibodies: The Relationship of the Sm and Rnaprotein (MO) Systems in Sle Sera¹

From the Departments of Medicine and Biochemistry, Veteran's Administration Hospital and School of Medicine, State University of New York, Buffalo, New York 14215

Abstract

An unexpected immunologic relationship was encountered when sera from patients with systemic lupus erythematosus directed against two different nuclear antigens in calf thymus extract were found to give a reaction of partial identity when reacted with a mixture of the antigens in agar diffusion experiments. Analysis of this antigenic mixture by absorption of the antigenic activity by monospecific antisera to such antigens has led to the conclusion that these two nuclear antigens designated Sm and Mo exist in calf thymus extract as a molecular complex. In addition to this physical association, human systemic lupus erythematosus sera containing anti-Sm were found to have an inordinately high concurrence of anti-Mo (17 of 19 sera).

Footnotes

¹ This work was supported by United State Public Health Service Research Grant AM10428 and by Designated Research Funds from the Veterans Administration.

² Recipient of Career Development Award 5KO3 AM-20-729 from the United States Public Health Service.

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