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Antigen-Induced Depression of DNA Synthesis in Mouse Spleen¹

From the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

Depression of DNA synthesis was demonstrated in mouse spleen after intravenous administration of sheep erythrocytes, Salmonella typhi H antigen, or keyhole limpet hemocyanin. This depression was maximal when antigen preceded injection of the DNA precursor IUDR-¹²⁵I by 6 hr, and varied with the dose of antigen administered. Antigen-induced depression of DNA synthesis was not affected by adrenalectomy, but was abolished 4 weeks after adult thymectomy, and could not be elicited by thymus-independent antigens. The possible mechanisms whereby a labile thymus-derived cell population exhibits a suppressor function in response to antigen are considered.

Footnotes

¹ This work was supported in part by American Cancer Society Grant E-613 and the National Institutes of Health Grant CA-14108.

² Marion Zatz is a recipient of a postdoctoral fellowship from the Damon Runyon Memorial Fund for Cancer Research. Present address: Departments of Surgery and Microbiology, Yale University School of Medicine, New Haven, Connecticut 06511.

³ Allan L. Goldstein is a recipient of a career scientist award from the Health Research Council of the City of New York. Present address: Department of Human Biological Chemistry and Genetics, Division of Biochemistry, The University of Texas Medical Branch, Galveston, Texas 77550.