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From the Departments of Pediatrics and Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14222
Abstract
Antibody response to poliovirus type I in serum, the nasopharynx, and the secretions of the genital tract was studied in human volunteers after intravaginal, intrauterine, nasopharyngeal, or intramuscular immunization with inactivated poliovaccine. The techniques of radioimmunodiffusion and autoradiography with P32 labeled poliovirus as the antigen were employed to determine antibody activity in the major classes of immunoglobulin in serum and secretions. Intravaginal and intrauterine immunization consistently resulted in the appearance of secretory antibody to poliovirus in the genital tract. The vaginal response was predominantly of 
A immunoglobulin, while the response in the uterus was essentially limited to G immunoglobulin. Intramuscular immunization resulted in a delayed appearance of G response in the genital tract, which could be correlated with the highest G antibody titers in the serum. No genital A response was observed, however, after such immunization. These observations provide evidence for local synthesis of poliovirus antibody in the genital tract, and its implication may be applicable to other genital infections.
Footnotes
1 This work was supported by Research Grants (AI09769) from the National Institute of Allergy and Infectious Disease and HD06321-01 from the National Institute of Child Health and Human Development.
2 Reprint address: Children's Hospital, Division of Virology, 219 Bryant Street, Buffalo, New York 14222.
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