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Role of the Thymus in Tolerance

X. "Suppressor" Activity of Antigen-Stimulated Rat Thymocytes Transferred to Normal Recipients¹

From the Department of Microbiology, Yale University, New Haven, Connecticut 06510

Abstract

Thymocytes or spleen cells were transferred from normal adult Lewis rats that had received 100 mg bovine -globulin intraperitoneally to intact adult syngeneic recipients. The recipients, after challenge at 24 hr with antigen in complete adjuvant, showed inhibition of the Arthus and delayed hypersensitivity responses and a slight delay in the formation of hemagglutinating and hemolytic antibody but not anaphylactic antibody. The effect was specific and apparently was not due to transferred antigen (transfer of killed thymocytes or spleen cells had no effect); it was observed between 18 and 72 hr after the injection of bovine -globulin in donor animals.

Footnotes

¹ This study was supported by Grants AI-06112 and AI-06455 of the National Institutes of Health.

² On leave of absence from the Department of Bacteriology, Chon-Nam University Medical School, Chon-Nam, Korea.