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Effect of Chronic Viral Infection on the Immune System

I. Comparison of the Immune Responsiveness of Mice Chronically Infected with LCM Virus with That of Noninfected Mice¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Immunoresponsiveness has been compared in mice chronically infected with lymphocytic choriomeningitis (LCM) virus and in noninfected mice. The antigens used were sheep red blood cells, keyhole limpet hemocyanin, human IgG (HuIgG), bovine IgG, chicken IgG, and turkey IgG. LCM-infected mice were found to have normal immune responses to sheep red blood cells and keyhole limpet hemocyanin over wide dose ranges, whereas against mammalian and avian IgG, LCM-infected mice showed depressed immune responsiveness. This depression in immune responses was not associated with differences in antibody avidity or antigen handling but with decreased numbers of antibody-forming cells. Unresponsiveness to HuIgG was difficult to induce with deaggregated antigen in mice chronically infected with LCM virus.

Footnotes

¹ This is publication No. 649 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif. This research was supported by the Violet June Kertell Memorial Grant for Research on Multiple Sclerosis from the National Multiple Sclerosis Society, United States Public Health Service Grant AI-07007, and Atomic Energy Commission Contract AT(04-3)-410.

² Recipient of Career Development Award AI-42580 AID from the United States Public Health Service.

³ Supported by a Dernham Senior Fellowship (D202) of the American Cancer Society, California Division.

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