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From the Department of Pathology, and Laboratory for Carbohydrate Research and Departments of Biological Chemistry and Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114
Abstract
Loss of specificity in the strain A mammary ascites carcinoma subline TA3-Ha appears to be related to decreased immunogenicity rather than to increased immunoresistance. Allogeneic hosts could be induced to reject potentially lethal inocula of TA3-Ha cells by addition of cells from the more specific TA3-St subline or by presensitization with skin grafts from strain A mice. The nonspecific TA3-Ha subline absorbed markedly less activity from H-2 antisera than strain-specific TA3-St cells; however, the absorption capacity of nonspecific TA3-Ha cells for H-2 antisera was noticeably increased by lyophilization, suggesting decreased exposure of H-2 antigens at the cell surface of intact TA3-Ha cells. It is suggested that inaccessibility of histocompatibility antigens on the TA3-Ha cell may be related to presence of a unique sialoglycoprotein at the cell surface in this tumor subline. With the strain-specific TA3-St subline, lyophilization increased H-2k antigenicity while decreasing H-2d activity. The magnitude of these changes, however, was much less than that observed with either H-2d or H-2k antigenicity after lyophilization of TA3-Ha cells.
Footnotes
1 This work was supported by United States Public Health Service Grants CA11091 and CA08418 from the National Cancer Institute.
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