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The Journal of Immunology, 1973, 110: 1216-1221.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Decline in Mixed Lymphocyte Reactivity of Spleen Cells from Aged Mice of a Long-Lived Strain1

T. G. Konen2, G. S. Smith and R. L. Walford

From the Department of Pathology, U.C.L.A. School of Medicine, Los Angeles, California 90024

Abstract

The mixed lymphocyte reaction was measured in male C57BL/6J mice 21 to 25 weeks, 90 to 94 weeks, and 150 weeks of age. A statistically significant decline in reactivity was noted for the oldest group of mice, compared to both younger groups. These results are interpreted in relation to survival patterns and age-specific incidences of spontaneous neoplasia in this long-lived strain.

Footnotes

1 This work was supported by United States Public Health Service Grants HD-534 and CA-12788 from the National Institutes of Health.

2 Supported by United States Public Health Service General Research Support Grant 1-SOLFR05354.






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