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The Journal of Immunology, 1973, 110: 959-967.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Modulation of Immunoglobulin Ontogeny in the Chicken: Effect of Purified Antibody Specific for µ Chain on IgM, IgY, and IgA Production1

Gerrie A. Leslie and Louis N. Martin

From the Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Abstract

The administration of anti-µ antibody to chick embryos in conjunction with bursectomy at hatch resulted in long-term suppression of IgM, IgY, and IgA synthesis. Anti-µ-suppressed chickens had less ability to produce antibody than bursectomized controls. Graft-vs-host responsiveness was normal or enhanced, indicative of the specific effect of anti-µ on bursa-dependent lymphocytes. Suppression of IgM, IgY, and IgA production could be achieved by anti-µ injection of 18-day-old embryos, providing evidence that IgY- and IgA-forming cells develop subsequent to that time. Repeated injection of anti-µ in early life was capable of producing abnormalities in immunoglobulin synthesis, including long-term IgY and IgA deficiency. These results were discussed in terms of the concept that IgY- and IgA-forming cells are derived from IgM-forming precursors.

Footnotes

1 This work was supported in part by National Science Foundation Grant GB-31001 and a grant from The John A. Hartford Foundation, Inc. The investigation was also supported by National Institutes of Health Training Grant GM-79. Taken from a dissertation submitted by Louis N. Martin to the Department of Microbiology and Immunology in partial fulfillment of the requirements for the Ph.D. degree.






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