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The Journal of Immunology, 1973, 110: 943-950.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Evolutionary Studies of Rabbit Allotypes1

I. Pathways for a and B Locus Markers

L. Scott Rodkey and Ernil Hansen2

From the Division of Biology, Kansas State University, Manhattan, Kansas 66502

Abstract

Preparations of IgG F(ab')2 fragments from domestic rabbits (NZW), hares (JR), and cottontail rabbits (Cot) were compared by indirect radioimmunoassay inhibition techniques for a comparison of the interrelatedness of the antigenic determinants reacting with anti-NZW allotype antisera.

JR F(ab')2 molecules that were reactive with anti-NZW allotype antisera did not inhibit a reaction of NZW molecules with anti-allotype antisera. In another inhibition system, unlabeled JR molecules inhibited a reaction between I*JR molecules and anti-NZW allotype antisera better than did the homologous unlabeled NZW molecules. A third genus (Cot) was used for comparison and the results of the study suggested that the reactions observed could be explained best by the presence of different numbers of antigenic determinant sites shared between the three species that are identified by anti-NZW allotype antisera.

The present data appear to favor the presence of a limited number of germ line genes coding for variable regions of Ig molecules since the time for evolving numerous identical mutations in each of thousands of germ line genes is limited to less than 2 x 106 years in lagomorphs.

Footnotes

1 This study was supported by National Institutes of Health Grant AI 10372 and National Institutes of Health Biomedical Sciences Support Grant FR 7036 to Kansas State University. It is Contribution 1170. Division of Biology. Kansas Agricultural Experiment Station, Manhattan, Kansas 66502.

2 Present address: Ludwig-Maximilian University, Munich, West Germany.






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