The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1973, 110: 905-910.
Copyright © 1973 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richardson, W. P.
Right arrow Articles by Paterson, P. Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Richardson, W. P.
Right arrow Articles by Paterson, P. Y.

On the Transfer of DNP-BSA Hypersensitivity in Guinea Pigs by Means of Irradiated Donor Plasma. Evidence That the Cutaneous Reactivity Is Hapten-Specific and Mediated Via DNP Antibody1

Walter P. Richardson2 and Philip Y. Paterson

From the Samuel J. Sackett Research Laboratories and the Infectious Diseases-Hypersensitivity Section, Department of Medicine, Northwestern University-McGaw Medical Center, Chicago, Illinois 60611

Abstract

Cutaneous sensitivity to 2,4-dinitrophenylated bovine serum albumin was transferred with plasma from sensitized, irradiated guinea pigs following the procedure of Dupuy and Good (1). Enhanced cutaneous reactivity was observed in recipients of plasma from irradiated (800 rads) donors as compared to plasma from nonirradiated donors. Cutaneous reactions of plasma recipients were greater at 3 to 4 hr than at 24 hr after skin testing and they exhibited clear-cut hapten, as opposed to carrier, specificity. The plasma used to transfer this sensitivity contained precipitating antibody which also was hapten-specific. These data demonstrate that the transferred sensitivity was "immediate" and due to circulating, precipitating DNP antibody producing a toxic antigen-antibody complex reaction of the Arthus type.

Footnotes

1 This work was supported in part by Research Grant NB-06262 from the National Institute of Neurologic Diseases and Stroke and Training Grant AM-05069 from the National Institute of Arthritis and Metabolic Diseases.

2 Dr. Richardson was a Public Health Service trainee under Grant AM-05069 from the National Institute of Arthritis and Metabolic Diseases.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1973 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1973 by The American Association of Immunologists, Inc. All rights reserved.