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Studies on the Control of Antibody Synthesis

IV. Effect of Tolerance Induction in Adult Rabbits on Antibody-Binding Affinity¹

From the Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York, New York 10021

Abstract

A single intravenous injection of antigen in adult rabbits was shown to depress specifically antibody synthesis upon subsequent immunization with antigen in complete Freund's adjuvant. The degree of tolerance was dependent upon the dose of antigen and the time interval between intravenous antigen and immunization with antigen in adjuvant. Tolerance could not be transferred passively to normal rabbits with serum from tolerant animals and could not be overcome by using a supraoptimal immunizing dose of antigen in Freund's adjuvant. Partial tolerance resulted in a moderate depression in the average affinity of the antibody synthesized.

Footnotes

¹ This work was supported in part by United States Public Health Service Research Grant AM-13701.

² Career Scientist of the Health Research Council of the City of New York under Investigatorship I-593.