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Human Blood T Cells: Response to Phytohemagglutinin¹

From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122

Abstract

Evidence has accumulated to indicate that two different populations of lymphocytes are responsible for immunologic responsiveness. The functional characteristics of these cells appear to differ; thymic-derived or T lymphocytes³ are associated with cellular immune responses whereas B lymphocytes (probably bone marrow-derived or bursa-dependent) have been implicated in humoral aspects of the immune response (1). The isolation and characterization of T and B lymphocytes are essential for a full assessment of their functions.

Recently surface markers on lymphocytes have provided a tool for identifying their origin. With direct immunofluorescent technique, lymphocytes with surface immunoglobulins have been shown in animals to be bone marrow- or bursa-derived, whereas lymphocytes of thymic origins are not stained by this technique (2–4). On the basis of this distinction it has been suggested that human peripheral blood lymphocytes bearing immunoglobulins are also B cells (5).

Footnotes

¹ This work was supported in part by United States Public Health Service Grant HD-05894, American Cancer Society Grant IC-76F, and the Jane Coffin Childs Memorial Fund for Medical Research.

³ Abbreviations used in this paper: T, thymusderived; B, bone marrow-derived or bursa-dependent; SRBC, sheep red blood cells; RFC, rosette-forming cells; PHA, phytohemagglutinin; PBS, phosphate-buffered saline.

² Please address correspondence to: Dr. H. Hugh Fudenberg, Section of Hematology and Immunology, Department of Medicine (475-HSW), University of California School of Medicine, San Francisco, California 94122.