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Rabbit Antiserum to Brain-Associated Thymus Antigens of Mouse and Rat

II. Analysis of Species-Specific and Cross-Reacting Antibodies¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Rabbit anti-mouse brain and anti-rat brain sera detect thymic antigens unique to mice and rats, respectively, and detect antigens shared by these two species. Specifically, C3H and AKR murine phenotype cells share with rats an heteroantigenic determinant not revealed by alloanti- serum because of an unresponsive state among mice to this determinant. AKR thymocytes share with rat thymocytes an additional antigen, most likely associated with the AKR alloantigen. Tissue distribution of the species-specific and shared markers was compatible with that of the classical alloantigens.

Footnotes

¹ This is publication 656 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. The work was supported by United States Public Health Service Grant AI-07007, Atomic Energy Commission Contracts AT (04-3)-410 and AT (04-3)-779 and American Cancer Society Grant T-519.

² Supported by United States Public Health Service Training Grant 5TOIGM00683-12.

³ Supported by Deutsche Forschungsgeneinschaft, 5320 Bad Godesberg, Kennedyalle 40, Forschungsstipendium PE 151/2.

⁴ Supported by United States Public Health Services Research Career Award No. 5-K6-GM-6936.