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Rabbit Antiserum to Brain-Associated Thymus Antigens of Mouse and Rat

I. Demonstration of Antibodies Cross-Reacting to T Cells of Both Species¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Immunization of rabbits with either mouse (CBA/ST) or rat (Le) brain homogenates results in the production of antisera which upon appropriate absorptions are T cell-specific for both mouse and rat. These antisera may be used effectively for direct cytotoxicity and detection of rat and mouse T cells by direct immunofluorescence. Furthermore, in the rat, it was demonstrated that antimouse brain serum, in the presence of complement, abrogates cell-mediated immunity in vitro, but does not affect antibody-forming cells.

Footnotes

¹ This is Publication 643 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. The work was supported by United States Public Health Service Grant AI-07007, Atomic Energy Commission Contracts AT (04-3)-410 and AT (04-3)-779, and American Cancer Society Grant T-519.

² Supported by Deutsche Forschungsgemeinschaft, 5320 Bad Godesberg, Kennedyalle 40, Forschungsstipendium PE 151/2.

³ Supported by United States Public Health Service Training Grant 5TOIGM00683-12.

⁴ Supported by United States Public Health Services Research Career Award 5-K6-GM-6936.