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Restoration of Immunocompetency in Tolerant Lymphoid Cell Populations by Cellular Supplementation¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Reconstitution experiments demonstrate that in mice the induction of unresponsiveness to human globulin (HGG) occurs more rapidly in specific bone marrow-derived (B) cells of the spleen (<3 days) than the previously reported induction period required for unresponsiveness in specific B cells of the bone marrow (8 to 15 days). This temporal variance could not be attributed to a difference in the gross localization of tolerogen in the respective lymphoid tissues. In contrast, the maintenance of the unresponsive state was similar in both B cell populations (40 to 50 days). Accordingly, the restoration of immunocompetency in unresponsive spleens could be accomplished in an adoptive transfer system by the addition of syngeneic thymocytes only at times predictable by the temporal pattern of the spontaneous loss of unresponsiveness described for bone marrow cells. The mere adoptive transfer of syngeneic thymocytes into tolerant animals did not similarly affect the unresponsive state.

Footnotes

¹ This is Publication 654 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation. The work was supported by United States Public Health Service Grant AI-07007, American Cancer Grant T-519, and Atomic Energy Commission Contract AT (04-03)-410.

² Supported by Dernham Senior Fellowship D-202 of the California Division of the American Cancer Society.

³ Supported by United States Public Health Research Award 4-K06-GM06936.