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The Presence of J-Chains in the Intracellular Fluid of IgM-Secreting Murine Tumor Cells¹

From the Department of Microbiology, University of Georgia, Athens, Georgia 30602

Abstract

The cells from the murine tumor HPC 76 secrete IgM. The intracellular fluid was analyzed for the presence of the J-chain. Subsequent to analytical polyacrylamide gel electrophoresis a band was observed which had migrated most rapidly anodally. Its position was similar to that of the ostensible J-chain derived from sulfonated IgM, sulfonated IgA, and the intracellular fluid from the IgA-producing MOPC 315 tumor cells. Intracellular J-chains also were precipitable with specific antiserum. The antibodies recognized identical J-chain antigens in sulfonated IgM, sulfonated IgA, and in the intracellular and extracellular fluids of the HPC 76 cells.

Footnotes

¹ This research was supported by a grant from the National Science Foundation (GB-8449 A-1).