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Intestinal Sphingoglycolipids with A and Le^a Activity from Humans and A, H-Like and Le^b-Like Activity from Dogs¹

From the Departments of Microbiology, Biochemistry and Clinical Pathology, University of Alabama in Birmingham, Alabama 35233

Abstract

Glycolipids containing fucose (fuco-lipids) have been shown to constitute an individual specific class of compounds both in humans and dogs. Since only trace amounts of some fuco-lipids can be isolated, immunologic techniques are invaluable in identifying these compounds and giving some insight into their structure. By using human and rabbit antisera and ulex lectin with precipitation and agglutination techniques, fuco-lipids isolated from human small intestine were shown to have human A and Le^a blood group activity. Fuco-lipids isolated from dog small intestine had human A, H-like and Le^b-like blood group activity. With fluorescein-labeled rabbit antisera it was demonstrated that Forssman activity was associated with the lamina propria whereas Le^b-like activity was in the glandular epithelium of the small intestine.

Footnotes

¹ This work was supported by Grants GB 13804 and GB 15605 from the National Science Foundation, the American Cancer IN-66K Grant and Grant 5-T01-DE-7 from the National Institutes of Health.