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The Journal of Immunology, 1973, 110: 880-883.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Site of Action of Cortisol in Cellular Immunity1

William L. Weston, Henry N. Claman and Gerald G. Krueger

Division of Dermatology and Division of Immunology, Department of Medicine, University of Colorado Medical Center, 4200 East Ninth Avenue, Denver, Colorado 80220

Abstract

Cell-mediated immunity reactions involve antigen-sensitive lymphocytes and monocytemacrophages. These reactions are inhibited by cortisol. To elucidate the site of inhibition by cortisol, we used an in vitro test of cellular immunity, the macrophage aggregation factor (MAF) assay. 10-3 M cortisol did not prevent sensitized lymphocytes from manufacturing and releasing MAF, but did prevent nonimmune macrophages from responding to MAF.

The location of inhibition of cortisol in cell-mediated immune responses is between the lymphokine and the monocyte-macrophage.

Footnotes

1 Supported in part by NIH Special Fellowship AM 54242-01 and USPHS Grants AI-TI-0013 and AM 10145.






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