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Three New Immunologic Types of Trachoma-Inclusion Conjunctivities Organisms¹

Department of Pathobiology and the Department of Epidemiology and International Health, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195, and the United States Naval Medical Research Unit No. 2, Box 14, APO San Francisco 96263

Abstract

Trachoma-inclusion conjunctivitis (TRIC) and lymphogranuloma venereum (LGV) organisms are closely related. Utilizing protection of mice from toxic death by prior immunization and more recently an indirect micro immunofluorescence technique, we have described six immunologic types, A through F, of TRIC organisms and three types of LGV. This report describes three new types of TRIC organisms, G, H and I. While H and I are almost completely unique immunologically, type G has cross-reactions with type F and appears to be an immunologic bridge between the previously unique F type and the B-, Ba-, D-, E- and LGV-related types. Strains of the three new types have been isolated almost entirely from the genital tract and biologically resemble the TRIC types D, E and F which have also been associated primarily with genital infection.

Footnotes

¹ This study was supported by United States Public Health Service Research Grant 5-R01-EY-00219 from the National Eye Institute. The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the Naval Service at large.

² Dr. James L. Gale is the recipient of United States Public Health Service Career Development Award 5K04 AI 42719-AID.