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Immunoglobulin Synthesis in Bullfrog Larvae¹

Department of Anatomy, School of Medicine, University of California, Los Angeles, California 90024

Abstract

The antibody-synthesizing capacity of tadpoles (Rana catesbeiana) has been studied with sheep erythrocytes as antigen. Tadpoles can mount an immune response similar to that seen in higher vertebrates except for a slower kinetic profile. They could not, however, be stimulated to elicit a true anamnestic response. The antibody had characteristics indicating that it probably was all IgM like. Use of the hemolytic plaque technique with various lymphoid organs detected synthesis of antibody in spleen, lymph gland and thymus.

Footnotes

¹ This work was supported by NSF Grant GB17767, two grants from the California Institute for Cancer Research and a grant from the Brown-Hazen Corporation.

² Postdoctoral Trainee, Public Health Service Grant GM616 in Anatomical Sciences.

³ Predoctoral Trainee, Public Health Service Grant GM616 in Anatomical Sciences.

⁴ Please send all correspondence and reprint requests to: Edwin L. Cooper, Department of Anatomy, School of Medicine, University of California, Los Angeles, California 90024.