HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lotzová, E. Articles by Cudkowicz, G. Search for Related Content PubMed Articles by Lotzová, E. Articles by Cudkowicz, G.

Resistance of Irradiated F₁ Hybrid and Allogeneic Mice to Bone Marrow Grafts of NZB Donors¹

Department of Pathology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

Heavily irradiated mice of several inbred and F₁ hybrid strains were classified as resistant or susceptible to allogeneic or parental grafts of 10⁶ NZB bone marrow cells depending on the 5-day hemopoietic repopulation of host spleens. Several strains did not support the growth of donor cells despite the total-body irradiation. NZW x NZB F₁ mice resisted the growth of as many as 4 x 10⁷ parental cells, the strongest barrier ever observed in mice for marrow transplants. The failures of growth were due to host-anti-graft reactions depressible by pretreatment of recipients with cyclophosphamide or horse anti-mouse thymocyte serum. Analysis of the progeny of two separate backcrosses of F₁ mice to NZB indicated that two non-linked autosomal genes controlled resistance. One of these genes was in linkage group IX, 31.42 crossing-over units away from the D end of H-2, specifying or controlling the expression of alloantigen-like components of hemopoietic cells (Hh-gene). The second gene had an epistatic effect, probably by regulating the recognition of, or the reactivity to, Hh-gene products.

Footnotes

¹ Supported in part by United States Public Health Service Research Grants AM-13,969 and CA-12,844 from the National Institutes of Health, and by American Cancer Society Grant IC-35B.