HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Winfield, J. B. Articles by Alexander, C. B. Search for Related Content PubMed Articles by Winfield, J. B. Articles by Alexander, C. B.

Anti-p-Azobenzenearsonate Antibody of Restricted Heterogeneity

II. Idiotypes of Antibodies Produced During a 33-Month Period

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Anti-idiotype antisera were obtained by immunizing allotype-matched rabbits with anti-p-azobenzenearsonate antibody (anti-ars) from an individual rabbit after each of four courses of immunization. These sera were used to study the relationship between anti-ars produced over a span of 33 months. Antibodies of limited heterogeneity produced 21 months apart had very similar idiotypes. Components with related idiotypes were also demonstrated to be present in the more heterogeneous earlier and later antibodies.