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The Journal of Immunology, 1973, 110: 648-651.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Effect of Specific Antibody on the Antigen-Induced Proliferative Response of Rabbit Lymph Node Cells1

G. J. Thorbecke and G. W. Siskind2

Department of Pathology, New York University Medical School and the Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College

Abstract

High concentrations of antibody specifically inhibited the proliferative response of sensitized rabbit lymph node cells to antigen. In contrast, low concentrations of antibody, in the presence of a heat labile component of fresh serum, markedly augmented the antigen-stimulated uptake of thymidine by sensitized lymph node cells.

Footnotes

1 This work was supported by United States Public Health Service Grants AI-3076 and AM-13701.

2 Career Scientist of the Health Research Council of the City of New York under Investigatorship I-593.






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