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Genetic Control of the in Vitro Responses of Rat Peripheral Blood Lymphocytes to Phytohemagglutinin and Concanavalin A¹

Departments of Pathology and Medical Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104

Abstract

Incorporation of tritiated thymidine was used to quantitate the in vitro responses of rat peripheral blood lymphocytes to phytohemagglutinin (PHA) and concanavalin A (Con A). By this criterion, cells from Brown Norway (BN) rats respond less vigorously to these phytomitogens than cells from Lewis strain animals. Cells from (Lewis x BN) F₁ hybrids respond as well as cells from Lewis donors, so high responsiveness appears to be fully dominant over low responsiveness. Studies on the inheritance of mitogen response levels suggest that a single gene is of primary importance in regulating the level of response to both PHA and Con A. The locus involved is not closely linked to the major histocompatibility antigen locus, AgB.

Footnotes

¹ This study was supported by Grants AI-09275, GM-33294 and CA-05022 from the United States Public Health service and by the Cancer Memorial Fund, Hospital of the University of Pennsylvania.

² Present address: Department of Biochemistry, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104.

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