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Evolutionary Studies on the Expression of Allotype Markers on Rabbit Immunoglobulin Molecules¹

Division of Biology, Kansas State University, Manhattan, Kansas 66502

Abstract

Preparations of immunoglobulin F(ab')₂ molecules from individual cottontail sera were examined by indirect precipitation techniques for the expression of allotypic determinants expressed by the a and b loci in domestic rabbits. The data indicate that cottontail immunoglobulins express some but not all of the determinants specified by the a2, a3, b4 and b5 alleles in the domestic rabbit, but none of the determinants specified by the a1 allele in the domestic rabbit. Inhibition tests to compare the domestic rabbit allotype determinants expressed by individual cottontails suggested that the b4 and b5 markers carried by cottontail rabbits were similar from one positive individual to another, but that the a2 and the a3 determinants may differ from one positive individual to another.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI-10372 and National Institutes of Health Biomedical Sciences Support Grant FR-7036 to Kansas State University. Contribution 1168, Division of Biology, Kansas Agricultural Experiment Station, Manhattan, Kansas 66502.