HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nussenzweig, R. S. Articles by Chen, D. Search for Related Content PubMed Articles by Nussenzweig, R. S. Articles by Chen, D.

Antibodies against Sporozoites of Human and Simian Malaria Produced in Rats¹

From the Department of Preventive Medicine, New York University School of Medicine, New York, New York 10016

Abstract

The various methods commonly used for the detection of antimalarial antibodies employ, in nearly all instances, the erythrocytic stages of these parasites as antigen source (1). The antigenic components of the different stages of development of the malaria parasites, however, differ considerably, in spite of the existence of some shared or common antigens (2, 3). Furthermore, the common antigens do not account for all of the antigenic components of the parasites, nor do they include the functional, i.e., protective, antigens of the various developmental stages. This is suggested by the finding that rodents immunized with attenuated sporozoites become totally resistant to an otherwise lethal sporozoite inoculum, but remain fully susceptible to challenge with erythrocytic stages of the same parasite strain (4).

Anti-sporozoite antibodies, i.e., antibodies directed against the infective stages of all malaria parasites, have previously been shown to occur in avian and rodent malaria. In both instances, these antibodies were observed upon immunization of the animals with attenuated, irradiated sporozoites.

Footnotes

¹ This work was supported by N.I.H. Research Grant AI 08952, N.I.H. Training Grant AI 00361 and grants from the World Health Organization and the Pan American Health Organization.