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B-Cell Differentiation in the Splenic Environment: Acquired Susceptibility to the Helper Function of Irradiated T Cells¹

From the Department of Pathology, School of Medicine, State University of New York at Buffalo, New York 14214

Abstract

The in vivo helper function of specific thymic inducer cells in anti-sheep hemolytic responses was retained after exposure to 1000 rads of -rays, but not after 3000 rads. A prerequisite for B-T cell interactions involving irradiated T cells was the residence (i.e., differentiation) of bone marrow-derived precursor cells outside the bone cavities, e.g., in the spleens of irradiated nonthymectomized mice. It is suggested that reproductive viability of T cells is not essential for inducing M or G responses in vivo, and that the properties acquired by B cells in the splenic environment confer susceptibility to the effects of nonantigen-specific T-cell mediators.

Footnotes

¹ Research supported by United States Public Health Service Grants AM-13,969 and CA-12,844.

² Henry C. and Bertha H. Buswell Fellow in Pathology.