HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Scibienski, R. Articles by Sercarz, E. Search for Related Content PubMed Articles by Scibienski, R. Articles by Sercarz, E.

Suppression and Selection of B Cells during Lysozyme Tolerance in the Mouse¹

From the Department of Bacteriology, University of California, Los Angeles, California 90024

Abstract

Soon after tolerance induction, cross-reactive avian lysozymes terminate tolerance to hen lysozyme (HEL).³ The production of cross-reactive antibody at this stage indicates that the bone marrow-derived (B) cell compartment is still non-tolerant. Later, B cell tolerance is also induced, but it requires a longer exposure and a higher dose of antigen than does induction of thymus-derived (T) cell tolerance.

At a time during recovery from neonatal or adult tolerance to HEL, when HEL-reactive B cells can again be demonstrated, mice challenged with turkey lysozyme (TEL) produce only TEL-specific antibody. The possibility is suggested that TEL-specific B cells compete more favorably for available antigen than do the newly returning, cross-reactive B cells.

The reduced response to challenge in tolerant animals is discussed in relation to a model in which there are stringent stereospecific rules governing the presentation of antigen to B cells.

Footnotes

¹ This work was supported by Grants GB 5410 from the NSF and AI 08198 from the United States Public Health Service. R.S. was the recipient of a predoctoral fellowship (5-F01-GM-35, 714) from the National Institutes of Health.

³ Abbreviations used in this paper: GEL, gallinaceous egg white lysozymes, where B is bobwhite quail, H is hen, J is Japanese quail, P is pea hen, R is ring-necked pheasant and T is turkey. Additional abbreviations: T, thymus-derived; B, bone marrow-derived; PT, post-administration of tolerogen; BSA, bovine serum albumin.

² Submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy, University of California, Los Angeles. Present address: Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616.