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Pseudoimmune Precipitation by the Isolated Byssinosis "Antigen"

From the M.R.C., Pneumoconiosis Unit, Llandough and Immunology Research Laboratory, Sully Hospital, Glamorgan, Great Britain

Abstract

The so-called cotton antigen, a polymer of 5,7,3',4' tetrahydroxyflavan 3–4 diol (THF) extracted from cotton plant bracts, precipitated 58% IgG, 54% IgM and 15% IgA in a sample of human serum and concurrently antibody activity in this serum to three physicochemically distinct antigens was reduced by 50%, 52% and 62%, respectively. THF also reacted with five myeloma IgG at dilutions equal to, or higher than, comparable dilutions of human serum and gave positive gel diffusion reactions with H and L chains, Fab and Fc pieces of IgG.

On the basis of these results it is suggested that human immunoglobulins are nonspecifically precipitated by the tannin-like polymer.

This article has been cited by other articles:

				A. A. Sekul and R. L. Ory Specific Antibody Response of Rabbits to Water Extracts of Cotton Dust and Bract Textile Research Journal, September 1, 1979; 49(9): 523 - 525. [Abstract] [PDF]