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Functional Heterogeneity of Murine Lymphoid Cells

III. Differential Responsiveness of T Cells to Phytohemagglutinin and Concanavalin A As a Probe for T Cell Subsets

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The mitogens phytohemagglutinin (PHA) and concanavalin A (Con A) stimulate only those mouse lymphocytes which have undergone differentiation within the thymus and thus bear the differentiation antigen . However, not all thymus-derived lymphocytes (T cells) react equally to both mitogens, and the differential responsiveness of T cells to PHA and Con A may be used to indicate the existence of T cell subsets. One subpopulation of T cells exists which demonstrates approximately equal reactivity to both mitogens and bears a relatively high density of determinants. Another subpopulation exists which responds mainly to Con A, and bears a relatively reduced density of determinants. T cell subsets so delineated also differ in their recirculation patterns, radiation sensitivities, location in peripheral lymphoid tissue, and most importantly, in their function. These differential characteristics may represent the capabilities of T cells in various stages of differentiation within one T cell line. On the other hand, these cells may be representative of two distinct T cell lines and preliminary evidence consistent with this possibility is presented.

Footnotes

¹ Present address: Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.

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