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Monoclonal IgA and IgM in the Serum of a Single Patient (SC)

II. Identity of Light Chains from IgA() and IgM()¹

From the Department of Biochemistry Research, Roswell Park Memorial Institute, ² Buffalo, New York 14203

Abstract

A comparative study was carried out with the light chains of IgA and IgM from a single patient (SC). Both light chains were of type and were homogeneous. They were not distinguished by urea disc electrophoresis, amino acid composition, N-terminal amino acid sequence (consequently V subgroup), Inv allotype and peptide map. Both were of V_III subgroup which is found in very low frequency among human chains. It appears that both light chains of SC IgA and SC IgM were synthesized by the same genes (the same variable portion gene and the same constant portion gene).

Footnotes

¹ This work was supported in part by Grant AI-8472 from the National Institute of Allergy and Infectious Diseases.

² A unit of the New York State Department of Health.