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Suppression of Delayed Hypersensitivity Reactions in Bursectomized Chickens by Passively Administered Anti-Immunoglobulin Antisera¹

From the Department of Pathology, New York University Medical Center, New York, New York

Abstract

Intravenous injection of rabbit anti-chicken immunoglobulin antisera (R anti-Ch IgG and R anti-Ch IgM) resulted in inhibition of delayed hypersensitivity (DH) reactions in bursectomized agammaglobulinemic chickens. Persistence of a high titer of circulating anti-Ig over the first 48 hr after challenge of sensitized chickens was correlated with effective inhibition of DH responses. Since both the R anti-Ch IgG and R anti-Ch IgM antisera had inhibitory effect, it is suggested that the anti-Ch L-chain component common to both antisera is responsible for inhibition. Mechanisms through which anti-Ig antibody might interfere with DH reactions are discussed.

Footnotes

¹ This work was supported by Grant AI 3076 from the United States Public Health Service.

² Postdoctoral Fellow of the Arthritis Foundation.

³ Career Scientist of the Health Research Council of the City of New York.

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