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Differential Effects of Cyclophosphamide on the B and T Cell Compartments of Adult Mice¹

From the Division of Experimental Biology and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77025

Abstract

Adult mice were given a single sublethal dose of cyclophosphamide. Effects of the drug on the bone marrow-derived (B) and thymus-derived (T) cell compartments were measured by studies on lymphocyte transformation, lymphoid tissue morphology and responsiveness to a primary injection of keyhole limpet hemocyanin. These studies indicated that the effect of cyclophosphamide on the B cell compartment was more severe and longer-lasting than the effect on the T cell compartment.

Footnotes

¹ This investigation was supported by United States Public Health Service Grants CA-05021, CA-12093, CA-03367, K6-CA-14, 219, AI-08227 and K4-AI-23820.

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