HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Waterfield, M. D. Articles by Todd, C. W. Search for Related Content PubMed Articles by Waterfield, M. D. Articles by Todd, C. W.

Rabbit Immunoglobulin Light Chains: Correlation of Variable Region Sequences with Allotypic Markers¹

From the Division of Biology, California Institute of Technology, Pasadena, California and the Department of Immunology, City of Hope National Medical Center, Duarte, California

Abstract

Evidence that the group b allotype markers correlate with certain mixtures of variable region sequences in rabbit immunoglobulin light chains is presented. The amino terminal sequences of chains from heterogeneous rabbit immunoglobulin of differing allotypes were examined by using an automatic protein sequenator. Each of the four allotypes has a distinctive pattern of amino acid residue alternatives over the first 20 amino terminal residues. Since previous studies have shown that amino acid sequences correlating with the allotypes are present in the constant region, our observations suggest that constant and variable region genes of chains may be closely linked.

Footnotes

¹ This work was supported by Grants AI-07995, AI-10781 and GM-06965 from the United States Public Health Service.

² Division of Biology, California Institute of Technology, Pasadena, California 91109.

³ Department of Immunology, City of Hope National Medical Center, Duarte, California 91010. Supported by Postdoctoral Fellowship AM-42920.

⁴ Department of Immunology, City of Hope National Medical Center, Duarte, California 91010. This work was made possible in part by a supporting fund established in the name of the M. B. Seretean Research Fellowship.