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Potentiated Reagin Response: Initiation with Minute Doses of Antigen and Alum Followed by Infection with Nippostrongylus Brasiliensis¹

From the Clinical Immunology, Arthritis and Allergy Units of the Medical Services, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114

Abstract

Intraperitoneal injection of 10 µg of egg albumin (EA) or keyhole limpet hemocyanin plus alum elicited a low titer reagin response in most male Sprague-Dawley rats. Infection with Nippostrongylus brasiliensis larvae served to potentiate the reagin response in many animals. The potentiated response yielded impressive reagin titers, at least in rats injected with EA, but was of short duration. The potentiated response appeared to be restricted to antibodies of the IgE class and did not involve IgG_a or IgG1 antibodies. Some attempts were made to elucidate the mechanism of the potentiated response.

Footnotes

¹ This is publication No. 578 of the Robert W. Lovett Memorial Unit for the Study of Diseases Causing Crippling at the Massachusetts General Hospital. This study was supported by Grants AI-10129 and AI-20638, AM-3564 and AM-5067, and by Grants from the Massachusetts Chapter, Arthritis Foundation and L. H. Bendit Foundation.