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Experiments on the Sensitivity of the Human Skin to the Toxin of the Bacillus of Shiga-Kruse

From the Clinic of Children's Diseases and the State Institute of Serological Research in Warsaw

Abstract

Experiments are presented showing that the negative skin reaction to the products of the Shiga-Kruse bacillus in human beings depends upon the presence of antitoxin in the blood. The antitoxin is specific, and, as in the case of "natural" immunity to diphtheria, it appears spontaneously in the individual, without a previous attack of the disease or artificial immunization. If this presence of dysenteric antitoxin in human beings provides an actual immunity against infection with dysentery, then the way must be open to attempt an active immunity in the same way as is done in respect to diphtheria and scarlet fever. We have actually begun to make this attempt with dysentery anatoxin. These experiments will be the suject of our next communication.