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Specific Resistance As Influenced by Nonspecific Agents

Allentown, Pennsylvania

Abstract

1. Distilled water employed intravenously failed to initiate antisheep hemolytic sensitizer production.

2. Without exception, a dose was found for each agency with which it was attempted to call forth increased sensitizer production that brought the desired result The same was also true as regards the elicitation of depression. Both protein and nonprotein agencies were used. Hypotonic, isotonic and hypertonic agencies were included.

3. Weekly bleeding apparently exerted no appreciable influence on sensitizer production.

4. Among the doses calling forth increased sensitizer production, it was always the larger dose that called forth the greater production.

5. The production of sensitizer following the use of the same dosage amount when employed subsequent to two sheep cell injections exceeded strikingly that following its use subsequent to only a single dose.

6. The dose used to elicit depression exceeded considerably that employed in eliciting increased production.

7. The amount of sensitizer produced when water and water containing increasing amounts of salts were injected subsequent to sheep cell injection, was inversely proportional to the amount of salt contained.

8. There was no appreciable difference in the production between water injection on the one hand and Ringer's solution and normal saline on the other. Nor was there any appreciable difference in the results obtained with saline on the one hand and saline containing the microörganisms in quantity to make the typhoid-paratyphoid agency on the other.