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The Journal of Immunology, 1972, 109: 1405-1407.
Copyright © 1972 by The American Association of Immunologists, Inc.
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The Effect of Surgical Bursectomy and Irradiation on Rosette-Forming Cells in the Chicken1

D. F. Kiszkiss, Y. S. Choi2 and R. A. Good

From the Research Laboratories of the Variety Club Heart Hospital Minneapolis, Minnesota 55455

Abstract

Heterologous erythrocytes are a useful antigen in studies of antigen-binding cells since their binding to lymphoid cells can be detected easily as rosettes of red cells around a central lymphocyte (1, 2). Such binding of antigen is believed to be an early stage in the development of both humoral and cellular immune responses. Because the humoral response to heterologous erythrocytes requires a synergism between thymus dependent (T)3 and bone marrow dependent (B) cells in the mouse (3, 4) and between T and bursal-derived cells in the chicken (5), it is important to assess the contribution of each to the population of rosette-forming cells (RFC). In an effort to explore the origin of RFC in the chicken, we have examined the effect of bursectomy and irradiation on the number of these cells, under conditions which, in normal animals, induce considerable RFC.

In the present report, we demonstrate that animals deprived of bursal influence from the embryonic period lack RFC.

Footnotes

1 This study was supported by grants from the United States Public Health Service and the National Foundation, March of Dimes.

3 Abbreviations used in this paper: T, thymus dependent; B, bone marrow dependent; RFC, rosette-forming cells; SRBC, sheep erythrocytes.

2 Career Development Awardee of the United States Public Health Service.






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